Ingredients Library

Most supplement labels tell you what’s in the bottle. Few explain why it’s there or what the research actually shows. This library covers the compounds in our formulas — mechanism, function, evidence, and which products it appears in.

Cardiovascular Health

Ingredients in this category support arterial health, lipid balance, blood viscosity, and cardiovascular resilience.

Bromelain is a proteolytic enzyme complex extracted from pineapple stem. It supports the breakdown of circulating proteins and is studied for its roles in tissue recovery and vascular clearance. In cardiovascular formulas, it works alongside nattokinase to support healthy blood flow.

Featured in: BioPurify

Supports:

  • Breakdown of inflammatory proteins in circulation
  • Healthy tissue repair and post-exercise recovery
  • Vascular clearance in combination with nattokinase

Clinical Research

Bromelain Ameliorates Atherosclerosis by Activating the TFEB-Mediated Autophagy and Antioxidant Pathways

Bromelain enhances nitric oxide bioavailability: Bradykinin’s link to TRPV1/Ca2+ /AMPK/autophagy signaling

Exploring the Therapeutic Potential of Bromelain: Applications, Benefits, and Mechanisms

Citrus bergamot is a flavonoid-rich citrus extract standardized to polyphenolic compounds, including the bergamot polyphenol fraction (BPF). These polyphenols interact with HMG-CoA reductase, the primary enzyme involved in cholesterol synthesis. Human clinical trials have evaluated standardized bergamot extract for effects on LDL, HDL, and triglyceride levels.

Featured in: BioPurify

Supports:

  • Healthy LDL cholesterol and triglyceride levels already within the normal range
  • Balanced HDL cholesterol
  • Natural modulation of cholesterol synthesis pathways

Clinical Research

Clinical application of bergamot (Citrus bergamia) for reducing high cholesterol and cardiovascular disease markers

Effect of bergamot on lipid profile in humans: A systematic review

Coenzyme Q10 is a fat-soluble compound produced throughout the body and concentrated in the heart and skeletal muscle. It plays a central role in mitochondrial ATP production and functions as a lipid-soluble antioxidant. Levels decline with age and are further reduced by statin-class medications, making supplementation particularly relevant for anyone managing long-term cardiovascular health.

Featured in: BioPurify

Supports:

  • ATP production in cardiac and skeletal muscle tissue
  • Antioxidant protection for the cardiovascular system
  • Replenishment of CoQ10 levels reduced by aging or statin use

Clinical Research

Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem

Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases

NAC is a stable, highly bioavailable precursor to glutathione — the body’s primary intracellular antioxidant. Beyond antioxidant support, NAC is studied for its role in healthy homocysteine metabolism, endothelial cell protection, and mucolytic activity in respiratory tissue.

Featured in: BioPurify, BioAmpMax

Supports:

  • Glutathione synthesis and total antioxidant defense
  • Healthy homocysteine metabolism
  • Protection of endothelial cells from oxidative stress

Clinical Research

Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study.

Oral N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid or smoking status

N-Acetylcysteine (NAC): Impacts on Human Health

Nattokinase is a serine protease enzyme derived from natto, a traditional Japanese fermented soybean product. It is studied in humans for its ability to support healthy fibrin levels in circulation, promote normal blood viscosity, and maintain blood pressure already within the normal range.

Featured in: BioPurify

Supports:

  • Healthy blood viscosity and circulatory flow
  • Fibrin breakdown in the bloodstream
  • Blood pressure already within the normal range

Clinical Research

Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases

Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Red yeast rice is a fermented grain product containing naturally occurring monacolins, including monacolin K, which shares structural similarities with statin compounds. It has been studied in human trials for its lipid-modulating effects, particularly in combination with CoQ10.

Featured in: BioPurify

Supports:

  • Healthy LDL cholesterol metabolism already within the normal range
  • Natural modulation of cholesterol production pathways
  • Lipid balance as part of a multi-compound cardiovascular formula

Clinical Research 

Red Yeast Rice for Hypercholesterolemia

Clinical evidence of efficacy of red yeast rice and berberine in a large controlled study versus diet

Tetrahydrocurcuminoids are the primary metabolites of curcumin and the form responsible for most of its antioxidant activity. Compared to standard curcumin, THc is colorless, more chemically stable, and significantly more bioavailable — making it the preferred form for formulas where absorption and potency matter.

Featured in: BioPurify

Supports:

  • Balanced inflammatory signaling at the cellular level, including NF-κB pathway modulation
  • Antioxidant defense with superior bioavailability to standard curcumin
  • Vascular and tissue health in combination with nattokinase and bromelain

Clinical Research

Tetrahydrocurcumin ameliorates postinfarction cardiac dysfunction and remodeling by inhibiting oxidative stress and preserving mitochondrial function via SIRT3 signaling pathway

The Role of Tetrahydrocurcumin in Tumor and Neurodegenerative Diseases Through Anti-Inflammatory Effects

Tetrahydrocurcumin ameliorates metabolic disorders associated with obesity by regulating gut microbiota homeostasis

Vitamin K2 as MK-7 is the long-chain menaquinone form of K2 with superior bioavailability and a longer half-life than MK-4. Its primary cardiovascular role is activating Matrix Gla-Protein (MGP), a protein that inhibits calcium deposition in arterial walls. It also activates osteocalcin, supporting calcium direction toward bone rather than soft tissue.

Featured in: BioPurify

Supports:

  • Inhibition of arterial calcium deposition via Matrix Gla-Protein activation
  • Bone density through osteocalcin activation
  • Arterial flexibility in combination with Vitamin D

Clinical Research

Vitamin K2—a neglected player in cardiovascular health: a narrative review

Growing Evidence of a Proven Mechanism Shows Vitamin K2 Can Impact Health Conditions Beyond Bone and Cardiovascular

Metabolic Health & Fat Metabolism

Ingredients in this category support energy expenditure, insulin sensitivity, fat oxidation, glucose regulation, and body composition.

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that regulates energy expenditure in fat tissue. By inhibiting NNMT, it may support metabolic activity in adipose cells and improve availability of NAD+ precursors. It is studied in research contexts for body composition and metabolic health applications.

Featured in: BioAmpMax

Supports:

  • NNMT inhibition to support metabolic activity in adipose tissue
  • NAD+ precursor availability through methyl donor pathways
  • Metabolic support in combination with AMPK-activating compounds

Clinical Research

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

Amlexanox is a small molecule that inhibits TBK1 and IKKε, two kinases involved in energy homeostasis and adipose tissue inflammation. Originally developed as an anti-inflammatory compound, it has been studied in human and animal models for its effects on insulin sensitivity and metabolic health in the context of obesity research.

Featured in: BioIgnite

Supports:

  • TBK1 and IKKε inhibition relevant to energy homeostasis
  • Metabolic activity in adipose tissue
  • Thermogenic response in combination with adrenergic compounds

Clinical Research

Amlexanox: A Novel Therapeutic for Atopic, Metabolic, and Inflammatory Disease

AOD-9604 is a synthetic peptide fragment derived from the C-terminus of human growth hormone, engineered to retain lipolytic activity without stimulating IGF-1 production. It is studied in research settings for fat metabolism and body composition applications.

Featured in: SHREDx

Supports:

  • Lipolysis and fat oxidation through GH-receptor-related pathways
  • Fat cell metabolism without IGF-1 stimulation
  • Metabolic support in combination with endurance-enhancing compounds

Clinical Research

Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone

Central and peripheral molecular targets for antiobesity pharmacotherapy

ATX-304 is a pan-AMPK activator designed to support cellular energy sensing pathways. AMPK is a master metabolic regulator involved in mitochondrial function, glucose uptake, and fatty acid oxidation. ATX-304 is studied in research contexts for its potential relevance across metabolic and longevity applications.

Featured in: BioAmp, BioAmpMax

Supports:

  • Pan-AMPK activation for cellular energy regulation
  • Mitochondrial function and glucose uptake support
  • Metabolic efficiency relevant to insulin sensitivity and fat oxidation

Clinical Research

AMPK activator ATX-304 reduces oxidative stress and improves MASLD via metabolic switching

The B-vitamins in BioAbsorb are provided as activated or methylated forms — pyridoxal-5-phosphate (B6), methylfolate (B9), and methylcobalamin (B12) — alongside riboflavin, thiamine, and pantothenate. Activated forms bypass common genetic polymorphisms (including MTHFR variants) that impair standard B-vitamin conversion, and are included as metabolic cofactors alongside the formula’s insulin-sensitizing compounds.

Featured in: BioAbsorb

Supports:

  • Mitochondrial energy metabolism and ATP production as essential cofactors
  • Methylation pathways supporting healthy homocysteine metabolism
  • Nutrient repletion alongside insulin-sensitizing and longevity compounds

Clinical Research

B Vitamins: Functions and Uses in Medicine

Mitochondrial function and toxicity: role of the B vitamin family on mitochondrial energy metabolism

BAM15 is a mitochondrial protonophore that acts as a selective uncoupler of the inner mitochondrial membrane. It supports thermogenesis by diverting energy away from ATP synthesis toward heat production — without affecting plasma membrane potential, which distinguishes it from older uncoupling agents studied in historical research.

Featured in: BioBam-15

Supports:

  • Mitochondrial uncoupling for thermogenic energy expenditure
  • Fat metabolism through increased caloric demand at the cellular level
  • Selective protonophoric activity with a favorable mitochondrial selectivity profile in research models

Clinical Research

BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases

Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice

Caffeine is a methylxanthine alkaloid that inhibits adenosine receptors, supporting alertness, thermogenesis, and fat oxidation. In BioIgnite, it is included at a moderate dose alongside L-theanine to support focused energy without excessive adrenergic load.

Featured in: BioIgnite

Supports:

  • Adenosine receptor inhibition for alertness and metabolic activation
  • Thermogenesis and fat oxidation
  • Focused energy in combination with L-theanine

Clinical Research

Caffeine effects on systemic metabolism, oxidative-inflammatory pathways, and exercise performance

Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis

Chromium picolinate is a highly bioavailable chelated form of chromium, a trace mineral involved in insulin receptor signaling and intracellular glucose transport. It is included in BioAmpMax as a cofactor to support carbohydrate and fat metabolism alongside inositol compounds.

Featured in: BioAmpMax

Supports:

  • Insulin receptor signaling and glucose uptake at the cellular level
  • Healthy carbohydrate metabolism already within the normal range
  • Cofactor activity alongside myo-inositol and D-chiro-inositol

Clinical Research

Molecular Mechanisms of Chromium in Alleviating Insulin Resistance

Chromium as a Modulator of Insulin Receptor Activity: A Systematic Review of Its Role in Metabolic Syndrome and Type 2 Diabetes

D-chiro-inositol is a secondary messenger in insulin signaling that is often depleted in states of insulin resistance. It works alongside myo-inositol to support cellular glucose uptake. Human research has evaluated the myo/D-chiro-inositol ratio as a factor in metabolic and reproductive health outcomes.

Featured in: BioAmpMax

Supports:

  • Insulin signaling as an intracellular secondary messenger
  • Glucose uptake at the cellular level
  • Synergistic metabolic support alongside myo-inositol

Clinical Research

D-Chiro-Inositol Glycans in Insulin Signaling and Insulin Resistance

D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes

DihydroBerberine is a reduced form of berberine with significantly higher oral bioavailability — estimated at roughly five times that of standard berberine. Like berberine, it activates AMPK and modulates glucose transport, but at lower doses and with less gastrointestinal friction, making it the preferred form for metabolic formulas.

Featured in: BioAbsorb

Supports:

  • AMPK activation for metabolic efficiency and cellular energy regulation
  • Healthy blood glucose and insulin sensitivity already within the normal range
  • Gut-compatible absorption compared to standard berberine at equivalent doses

Clinical Research

Absorption Kinetics of Berberine and Dihydroberberine and Their Impact on Glycemia: A Randomized, Controlled, Crossover Pilot Trial

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action

Dihydroberberine normalizes insulin secretion by regulating glucokinase

GW-501516 is a PPARδ agonist studied in research settings for its effects on fatty acid oxidation, endurance capacity, and metabolic gene expression.

Featured in: SHREDx

Supports:

  • PPARδ activation relevant to fatty acid oxidation
  • Endurance and oxidative metabolism in research models
  • Fat metabolism in combination with SLU-PP-332 and AOD-9604

Clinical Research

The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation

Myo-inositol is the most abundant form of inositol in the body, acting as a structural component of cell membranes and a key mediator of insulin signaling. It is one of the most studied inositol isomers in human clinical research, particularly for metabolic health and reproductive hormone support.

Featured in: BioAmpMax

Supports:

  • Insulin signaling and intracellular glucose uptake
  • Cell membrane integrity and phospholipid synthesis
  • Synergistic activity with D-chiro-inositol for metabolic and hormonal balance

Clinical Research

Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes

The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment

SLU-PP-332 is an ERRα/β/γ agonist that activates estrogen-related receptor pathways involved in mitochondrial biogenesis and oxidative metabolism. In preclinical research, it has shown exercise-mimetic metabolic effects in skeletal muscle, supporting fat oxidation and endurance-related gene expression without physical exercise.

Featured in: ShredMAX, SHREDx

Supports:

  • ERR receptor activation for mitochondrial biogenesis
  • Oxidative metabolism and fatty acid utilization
  • Exercise-mimetic metabolic responses in research models

Clinical Research

An orally active estrogen receptor–related receptor agonist, SLU-PP-915, enhances aerobic exercise capacity

A Synthetic ERR Agonist Alleviates Metabolic Syndrome

Taurine is a conditionally essential amino acid with roles in cardiovascular function, mitochondrial energy metabolism, and cellular osmoregulation. It is included in BioFlow as a supportive compound alongside tesofensine and magnesium L-threonate.

Featured in: BioFlow

Supports:

  • Cardiovascular function and blood flow regulation
  • Mitochondrial energy metabolism
  • Cellular osmoregulation and electrolyte balance

Clinical Research

The Anti-Inflammatory Effect of Taurine on Cardiovascular Disease

Functional Role of Taurine in Aging and Cardiovascular Health: An Updated Overview

Tesofensine is a triple monoamine reuptake inhibitor — blocking reuptake of serotonin, dopamine, and noradrenaline simultaneously. Originally developed for neurological research, it is studied at low doses for appetite regulation and metabolic rate in research settings.

Featured in: BioFlow

Supports:

  • Triple monoamine reuptake inhibition relevant to appetite and energy balance
  • Metabolic rate and caloric expenditure in research models
  • Appetite regulation at sub-clinical research doses

Clinical Research

Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial

Brain & Cognition

Ingredients in this category support neuroplasticity, neurotransmitter function, mental clarity, and cognitive performance.

Dihexa is a synthetic peptide derived from angiotensin IV with potent synaptogenic activity. It has been studied for its ability to enhance hepatocyte growth factor (HGF) receptor signaling in the brain, supporting the formation of new synaptic connections at concentrations significantly lower than other studied synaptogenic compounds.

Featured in: BioMind

Supports:

  • Synaptogenic activity through HGF pathway enhancement
  • Synaptic density and neuroplasticity in research models
  • Cognitive function in combination with neuroprotective compounds

Clinical Research

AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway

J-147 is a synthetic curcumin derivative that activates the mitochondrial protein ATP synthase and modulates BDNF signaling. Originally developed as a neuroprotective compound, it is studied in preclinical models for its effects on cognitive resilience, neurological aging, and mitochondrial function in the brain.

Featured in: BioMind

Supports:

  • ATP synthase activation relevant to neuronal energy metabolism
  • BDNF modulation for neuroprotective support
  • Cognitive resilience in combination with synaptogenic compounds

Clinical Research

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer’s disease mice

Current evidence for J147 as a potential therapeutic agent in nervous system disease: a narrative review

L-theanine is an amino acid found primarily in green tea. It promotes alpha-wave brain activity — associated with relaxed focus — and modulates glutamate receptor activity. It is routinely combined with caffeine to support focused alertness without overstimulation.

Featured in: BioIgnite

Supports:

  • Alpha-wave brain activity associated with calm, focused states
  • Glutamate receptor modulation
  • Cognitive performance in combination with caffeine

Clinical Research

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial

A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave®l-Theanine on Stress in a Healthy Adult Population

The combined effects of L-theanine and caffeine on cognitive performance and mood

High-dose L-theanine–caffeine combination improves neurobehavioural and neurophysiological measures of selective attention in acutely sleep-deprived young adults: a double-blind, placebo-controlled crossover study

Magnesium L-threonate is a form of magnesium developed for its ability to cross the blood-brain barrier and raise intraneuronal magnesium levels. Unlike other magnesium forms, it has been studied specifically for its effects on synaptic density, cognitive function, and short-term memory in human and animal research.

Featured in: BioFlow

Supports:

  • Blood-brain barrier permeation for central nervous system magnesium delivery
  • Synaptic plasticity and cognitive function
  • Neural magnesium levels associated with learning and memory

Clinical Research

Magnesium-L-threonate improves sleep quality and daytime functioning in adults with self-reported sleep problems: A randomized controlled trial

The effects of magnesium L-threonate (Magtein®) on cognitive performance and sleep quality in adults: a randomised, double-blind, placebo-controlled trial

Noopept is a synthetic dipeptide that modulates AMPA and NMDA receptors and increases expression of BDNF and NGF — neurotrophins involved in neuronal survival and plasticity. It is studied for nootropic, neuroprotective, and anxiolytic properties at low oral doses.

Featured in: BioMind

Supports:

  • AMPA and NMDA receptor modulation for cognitive performance
  • BDNF and NGF expression for neuroprotective support
  • Neuroplasticity in combination with synaptogenic compounds

Clinical Research

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

Gut Health & Digestive Support

Ingredients in this category support intestinal barrier integrity, mucosal repair, gut lining health, and digestive comfort.

BPC-157 is a synthetic pentadecapeptide derived from a sequence found in human gastric juice. It has been extensively studied in preclinical models for its effects on gut mucosal repair, intestinal barrier integrity, tendon healing, and systemic tissue regeneration. BioGutPro uses standard BPC-157; BioRestore uses BPC-157 arginine salt for improved oral stability.

Featured in: BioGutPro, BioRestore

Supports:

  • Gut mucosal repair and intestinal barrier integrity
  • Systemic tissue regeneration and connective tissue support
  • Recovery in combination with PEA, KPV, and other repair compounds

Clinical Research

Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review

Pentadecapeptide BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts

Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

CoreBiome tributyrin is a proprietary triglyceride form of butyric acid engineered to survive gastric transit and deliver butyrate directly to the colon. Butyrate is the primary fuel source for colonocytes and a key regulator of gut barrier integrity and mucosal inflammatory balance.

Featured in: BioGutPro

Supports:

  • Colonocyte energy supply through targeted butyrate delivery
  • Gut barrier integrity and mucosal health
  • Healthy inflammatory balance in the gut lining

Clinical Research

Tributyrin alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice

Tributyrin (CoreBiome®) enhances butyrate levels and modulates the gut microbiota, barrier function, and immune response in vitro

Tributyrin Attenuates Metabolic and Inflammatory Changes Associated with Obesity through a GPR109A-Dependent Mechanism

KPV is a tripeptide (Lys-Pro-Val) derived from the C-terminal region of alpha-melanocyte-stimulating hormone. It has been studied for anti-inflammatory properties at the gut mucosa level, including modulation of intestinal inflammatory signaling pathways. It is included in BioGutPro as a mucosal support compound alongside BPC-157 and larazotide.

Featured in: BioGutPro

Supports:

  • Anti-inflammatory signaling at the gut mucosa
  • Intestinal barrier support in combination with BPC-157
  • Mucosal protection during periods of gut inflammatory stress

Clinical Research

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

N-acetyl larazotide is a synthetic octapeptide that modulates the tight junction protein zonulin, which regulates intestinal permeability. It is studied in research settings as an intestinal barrier-preserving agent, and is included in BioGutPro to complement the mucosal repair activity of BPC-157 and KPV.

Featured in: BioGutPro

Supports:

  • Tight junction modulation for gut barrier integrity
  • Intestinal permeability regulation through zonulin pathways
  • Barrier support in combination with BPC-157 and KPV

Clinical Research

Larazotide Acetate Protects the Intestinal Mucosal Barrier from Anoxia/Reoxygenation Injury via Various Cellular Mechanisms

Larazotide Acetate for Persistent Symptoms of Celiac Disease Despite a Gluten-Free Diet: A Randomized Controlled Trial

Sodium bicarbonate is included in oral peptide formulas as a pH buffer. It creates a more alkaline microenvironment in the stomach that reduces acid degradation of sensitive peptide compounds, supporting the delivery and bioavailability of BPC-157 and other peptide ingredients.

Featured in: BioGutPro, BioRestore

Supports:

  • pH buffering to protect oral peptide compounds from gastric acid degradation
  • Improved stability and bioavailability of co-delivered peptide compounds
  • Gastric comfort as a buffering agent

Clinical Research

Strategies for overcoming multiple barriers of oral administration of protein and peptide therapeutics

Zinc L-carnosine is a chelated complex of zinc and the dipeptide carnosine. It has been evaluated in human clinical trials for its protective effects on the gastric and intestinal mucosa, where it appears to support mucosal integrity and help maintain the gut lining under inflammatory conditions.

Featured in: BioGutPro

Supports:

  • Gastric and intestinal mucosal protection
  • Targeted zinc delivery to gut tissue for barrier repair support
  • Gut lining health in combination with BPC-157 and tributyrin

Clinical Research

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders

The role of Zinc L-Carnosine in the prevention and treatment of gastrointestinal mucosal disease in humans: a review.

Recovery & Repair

Ingredients in this category support connective tissue resilience, inflammatory balance, joint health, and physical recovery.

GHK-Cu is a naturally occurring copper-binding tripeptide (Gly-His-Lys) found in human plasma and connective tissue. It has been studied for its roles in wound healing, skin tissue remodeling, and modulation of genes involved in tissue repair and inflammatory response regulation.

Featured in: BioGutPro

Supports:

  • Tissue repair and wound healing through copper-peptide signaling
  • Gene expression modulation relevant to regeneration and inflammatory balance
  • Skin and connective tissue support in combination with BPC-157

Clinical Research

The potential of GHK as an anti-aging peptide

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

Hyaluronic acid is a naturally occurring glycosaminoglycan found throughout connective tissue, joints, and the extracellular matrix of skin. Oral hyaluronic acid has been studied in human trials for its effects on joint lubrication, skin hydration, and tissue resilience during physical recovery.

Featured in: BioRestore

Supports:

  • Joint lubrication and connective tissue hydration
  • Skin elasticity and moisture retention
  • Tissue matrix support during recovery from physical stress

Clinical Research

Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence

Oral administration of hyaluronic acid to improve skin conditions via a randomized double‐blind clinical test

PEA is an endogenous fatty acid amide produced by the body in response to tissue stress and injury. It modulates PPAR-α receptors and mast cell activity, supporting a balanced inflammatory response and reducing peripheral pain signaling. It has been evaluated in multiple human clinical trials for pain and recovery applications.

Featured in: BioRestore

Supports:

  • PPAR-α receptor modulation for balanced inflammatory response
  • Peripheral pain signal reduction and tissue resilience
  • Recovery support in combination with BPC-157 and hyaluronic acid

Clinical Research

Palmitoylethanolamide in the Treatment of Chronic Pain: A Systematic Review and Meta-Analysis of Double-Blind Randomized Controlled Trials

Palmitoylethanolamide supplementation for human health: A state-of-the-art systematic review of Randomized Controlled Trials in patient populations

Longevity & Cellular Health

Ingredients in this category support mitochondrial function, mitophagy, antioxidant defense, and healthy cellular aging.

Alpha-lipoic acid (ALA) is a mitochondria-derived antioxidant compound that regenerates other antioxidants, including vitamins C and E and glutathione. BioRecharge uses R-alpha lipoic acid specifically — the biologically active isomer — rather than the racemic mixture used in most supplements.

Featured in: BioRecharge

Supports:

  • Mitochondrial antioxidant defense and glutathione regeneration
  • Recycling of vitamins C and E under oxidative stress conditions
  • Metabolic support through mitochondrial energy pathway involvement

Clinical Research

Therapeutic applications of alpha-lipoic acid: A review of clinical and preclinical evidence (1998–2024)

Alpha-Lipoic Acid: Biological Mechanisms and Health Benefits

C60 fullerene is a spherical carbon molecule consisting of 60 carbon atoms. Its structure allows it to neutralize multiple free radical species per molecule — a property distinct from conventional antioxidants that operate on a one-to-one electron-donation basis. It is included in BioRecharge as part of a multi-compound antioxidant and mitophagy support formula.

Featured in: BioRecharge

Supports:

  • Multi-radical neutralization capacity per molecule
  • Lipid peroxidation protection in cellular membranes
  • Antioxidant support in combination with urolithin A and alpha-lipoic acid

Clinical Research

Anti-Inflammatory and Antioxidant Effects of Liposoluble C60 at the Cellular, Molecular, and Whole-Animal Levels

Pomegranate extract provides ellagitannins — particularly punicalagins — that are converted by gut bacteria into urolithins. BioRecharge includes pomegranate extract alongside purified Urolithin A to provide both immediate urolithin delivery and ongoing precursor support for individuals whose gut microbiome is capable of the conversion.

Featured in: BioRecharge

Supports:

  • Ellagitannin delivery as a natural precursor to urolithin production
  • Antioxidant and polyphenol support through punicalagin content
  • Synergistic mitophagy support alongside purified Urolithin A

Clinical Research

Evidence for health properties of pomegranate juices and extracts beyond nutrition: A critical systematic review of human studies

Effects of Pomegranate Extract on Inflammatory Markers and Cardiometabolic Risk Factors in Adults Aged 55–70 Years: A Randomised Controlled Parallel Trial

Urolithin A is a gut microbiome-derived metabolite of ellagitannins found in pomegranates and other polyphenol-rich foods. It is the most studied activator of mitophagy — the selective autophagy-mediated clearance of damaged mitochondria — and has been evaluated in human clinical trials for effects on mitochondrial health, muscle function, and cellular energy capacity.

Featured in: BioRecharge

Supports:

  • Mitophagy activation for clearance of damaged or dysfunctional mitochondria
  • Mitochondrial quality and cellular energy capacity
  • Muscle function and exercise recovery as supported by human clinical data

Clinical Research

Targeting aging with urolithin A in humans: A systematic review

Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults

Peptide Bioregulators

Peptide bioregulators are short-chain peptide complexes derived from specific animal tissues and designed to support the normal function of corresponding tissues in the human body. Each BioLongevity bioregulator targets a single organ or system, providing tissue-specific peptide signaling support as part of a long-term wellness routine. All bioregulators in this catalog contain 40 mg of their respective peptide complex per capsule.

The adrenal peptide complex is a short-chain peptide fraction derived from adrenal gland tissue. Peptide bioregulators in this class are studied for their tissue-specific signaling properties, with adrenal-derived complexes positioned for adrenal function and stress-response support.

Featured in: BioAdrenal

Supports:

  • Normal adrenal gland cellular function
  • Adrenal system support as part of a long-term wellness routine
  • Tissue-specific peptide signaling for stress-response system health

The bladder peptide complex is a short-chain peptide fraction derived from bladder tissue. It is positioned for urinary tract function support and lower urinary system cellular health as part of a targeted bioregulator routine.

Featured in: BioBladder

Supports:

  • Normal bladder cell function and tissue integrity
  • Urinary tract health as part of a long-term wellness routine
  • Tissue-specific peptide signaling for bladder system support

The blood vessel peptide complex is a short-chain peptide fraction derived from vascular tissue. Vascular peptide complexes are among the most studied bioregulator categories and are positioned for endothelial and vascular smooth muscle support, circulatory health, and long-term cardiovascular wellness routines.

Featured in: BioBloodVessels, BioFemale, BioMale

Supports:

  • Normal endothelial cell function and vascular tissue integrity
  • Circulatory health and vascular system support
  • Tissue-specific peptide signaling as part of a cardiovascular longevity routine

The bone marrow peptide complex is a short-chain peptide fraction derived from bone marrow tissue. It is positioned for hematopoietic system support — the system responsible for producing red blood cells, white blood cells, and platelets — as part of a long-term immune and blood health routine.

Featured in: BioBoneMarrow

Supports:

  • Normal bone marrow cell function and hematopoietic tissue health
  • Blood cell production system support
  • Tissue-specific peptide signaling for immune and circulatory system maintenance

The cartilage and bone peptide complex is a short-chain peptide fraction derived from cartilage and bone tissue. It is positioned for joint, connective tissue, and skeletal health support, making it a commonly included bioregulator for active individuals and those supporting long-term musculoskeletal function.

Featured in: BioCartilage

Supports:

  • Normal cartilage and bone cell function
  • Joint comfort and connective tissue integrity
  • Tissue-specific peptide signaling for musculoskeletal longevity

The heart peptide complex is a short-chain peptide fraction derived from cardiac muscle tissue. It is positioned for myocardial cell support and cardiovascular function maintenance as part of a long-term cardiac health routine, and pairs naturally with the blood vessel bioregulator for comprehensive cardiovascular coverage.

Featured in: BioHeart

Supports:

  • Normal myocardial cell function and cardiac tissue integrity
  • Cardiovascular wellness support as part of a daily bioregulator routine
  • Tissue-specific peptide signaling for heart muscle health

The kidney peptide complex is a short-chain peptide fraction derived from renal tissue. It is positioned for kidney function and urinary system health support, covering renal cellular maintenance as part of a long-term wellness routine.

Featured in: BioKidney

Supports:

  • Normal kidney cell function and renal tissue integrity
  • Urinary system health as part of a targeted bioregulator protocol
  • Tissue-specific peptide signaling for long-term kidney support

The liver peptide complex is a short-chain peptide fraction derived from hepatic tissue. Liver bioregulators are among the most widely used in clinical bioregulator research, positioned for hepatic cell function, detoxification pathway support, and metabolic organ maintenance.

Featured in: BioLiver, BioFemale, BioMale

Supports:

  • Normal hepatic cell function and liver tissue integrity
  • Detoxification and metabolic organ support
  • Tissue-specific peptide signaling for long-term liver health

The lung peptide complex is a short-chain peptide fraction derived from bronchial mucosa tissue. It is positioned for respiratory epithelial cell support, lung tissue maintenance, and respiratory system wellness as part of a long-term health routine.

Featured in: BioLung

Supports:

  • Normal bronchial mucosa cell function and respiratory tissue integrity
  • Lung health and respiratory system support
  • Tissue-specific peptide signaling for long-term pulmonary wellness

The muscle peptide complex is a short-chain peptide fraction derived from triceps muscle tissue. It is positioned for skeletal muscle cell support, muscle metabolism, and function maintenance — relevant for active individuals as well as those focused on long-term musculoskeletal health.

Featured in: BioMuscle

Supports:

  • Normal skeletal muscle cell function and tissue integrity
  • Muscle metabolism support and physical performance maintenance
  • Tissue-specific peptide signaling for long-term muscle health

The nervous system peptide complex is a short-chain peptide fraction derived from brain tissue. It is one of the most studied bioregulator categories, positioned for neuronal cell support, cognitive function maintenance, and central nervous system wellness as part of a longevity routine.

Featured in: BioNervousSystem, BioFemale, BioMale

Supports:

  • Normal neuronal cell function and brain tissue integrity
  • Cognitive function and central nervous system support
  • Tissue-specific peptide signaling for long-term neurological wellness

The ovary peptide complex is a short-chain peptide fraction derived from ovarian tissue. It is positioned for female reproductive system support and ovarian function maintenance as part of a long-term hormonal health routine.

Featured in: BioOvary, BioFemale

Supports:

  • Normal ovarian cell function and reproductive tissue integrity
  • Female reproductive system support as part of a hormonal wellness routine
  • Tissue-specific peptide signaling for long-term ovarian health

The pancreas peptide complex is a short-chain peptide fraction derived from pancreatic tissue. It is positioned for pancreatic cell function and both endocrine (insulin production) and exocrine (digestive enzyme secretion) system support as part of a metabolic wellness routine.

Featured in: BioPancreas, BioMale

Supports:

  • Normal pancreatic cell function and tissue integrity
  • Endocrine and exocrine pancreatic system support
  • Tissue-specific peptide signaling for metabolic organ health

The parathyroid peptide complex is a short-chain peptide fraction derived from parathyroid gland tissue. It is positioned for parathyroid cell function and calcium metabolism regulation support, relevant to bone density, nerve signaling, and cardiovascular function.

Featured in: BioParathyroid

Supports:

  • Normal parathyroid cell function and gland tissue integrity
  • Calcium metabolism regulation support
  • Tissue-specific peptide signaling for parathyroid and bone system health

The pineal peptide complex is a short-chain peptide fraction derived from pineal gland tissue. The pineal gland produces melatonin and plays a central role in circadian rhythm regulation. Pineal bioregulators are positioned for circadian support, sleep quality, and neuroendocrine system maintenance as part of a longevity routine.

Featured in: BioPineal, BioFemale, BioMale

Supports:

  • Normal pineal cell function and gland tissue integrity
  • Circadian rhythm and sleep-wake cycle support
  • Tissue-specific peptide signaling for neuroendocrine system maintenance

The prostate peptide complex is a short-chain peptide fraction derived from bovine prostate tissue. It is positioned for prostate cell function and urinary health maintenance in men, and is commonly included in male longevity and hormone system support routines.

Featured in: BioProstate

Supports:

  • Normal prostate cell function and tissue integrity
  • Urinary flow and prostate health support in men
  • Tissue-specific peptide signaling for long-term male reproductive wellness

The retina peptide complex is a short-chain peptide fraction derived from eye tissue, covering retina, cornea, and ocular blood vessel components. It is positioned for visual system cellular health and long-term eye function support as part of a targeted bioregulator routine.

Featured in: BioRetina

Supports:

  • Normal retinal and corneal cell function and eye tissue integrity
  • Visual system support as part of a long-term ocular health routine
  • Tissue-specific peptide signaling for retinal and vascular eye tissue maintenance

The stomach peptide complex is a short-chain peptide fraction derived from gastric mucosa tissue. It is positioned for stomach cell metabolism and function support, gastric mucosal integrity, and digestive system maintenance as part of a gut health routine.

Featured in: BioStomach

Supports:

  • Normal gastric mucosal cell function and stomach tissue integrity
  • Digestive system support and gastric lining health
  • Tissue-specific peptide signaling for long-term stomach wellness

The testes peptide complex is a short-chain peptide fraction derived from testicular tissue. It is positioned for male reproductive system support, testosterone-producing cell health, and male hormonal wellness as part of a long-term routine.

Featured in: BioTestes, BioMale

Supports:

  • Normal testicular cell function and reproductive tissue integrity
  • Male hormonal wellness support within the context of a daily routine
  • Tissue-specific peptide signaling for long-term male reproductive health

The thymus peptide complex is a short-chain peptide fraction derived from thymus gland tissue. The thymus is the primary site of T-cell maturation and plays a central role in adaptive immune function. Thymus bioregulators are among the most studied in longevity research, with connections to immune system aging and thymic involution.

Featured in: BioThymus

Supports:

  • Normal thymic cell function and immune tissue integrity
  • T-cell support and adaptive immune system maintenance
  • Tissue-specific peptide signaling relevant to immune aging and thymic health

The thyroid peptide complex is a short-chain peptide fraction derived from thyroid gland tissue. It is positioned for thyroid cell function support and metabolic system maintenance, relevant to energy regulation, body temperature, and hormonal balance as part of a long-term wellness routine.

Featured in: BioThyroid, BioFemale

Supports:

  • Normal thyroid cell function and gland tissue integrity
  • Metabolic rate and energy regulation support through thyroid system maintenance
  • Tissue-specific peptide signaling for long-term thyroid health

Clinical Research (Studies to be added)